Pharmacological properties of modafinil in rat hippocampus pyramidal neurons
- VernacularTitle:莫达非尼对大鼠海马神经元I_(GABA)的抑制作用机制
- Author:
Yuanyin WANG
;
Qing HUANG
;
Hui TANG
;
Liecheng WANG
- Publication Type:Journal Article
- Keywords:
modafinil;
GABA;
ATP-sensitive potassium channel;
hippocampus;
patch clamp
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effects of a novel psychoactive drug,modafinil,on the GABAA receptor-induced current in rat hippocampus pyramidal neurons.Methods Whole-cell patch-clamp recordings were applied in cultured hippocampus pyramidal neurons.Results The GABA-activated currents were blocked by bicuculline,a competitive antagonist of GABAA receptor.Modafinil could partly inhibit IGABA.Pre-treating hippocampus neurons with glibenclamide for 30 min,modafinil-induced inhibition on IGABA was removed.Conclusion Modafinil is different from other psychostimulants.The protection of modafinil may be via modulating ATP sensitive potassium channel activation.
