Formulation and preparation of glycyrrhizic acid solid lipid nanoparticles
- VernacularTitle:甘草酸固体脂质纳米粒的处方及制备工艺
- Author:
Jun HOU
;
Shiwen ZHOU
- Publication Type:Journal Article
- Keywords:
glycyrrhizic acid;
solid lipid nanoparticle;
orthogonal design;
encapsulation;
drug loading
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare the glycyrrhizic acid solid lipid nanoparticles(GL-SLN).Methods GL-SLN was prepared by conventional rotary-evaporated film-ultrasonication method.Based on the single-factor experiment,GL-SLN was prepared using orthogonal design for optimization of formulation and technology.The obtained GL-SLN was also evaluated.Results GL-SLN had even and regular appearance and the average diameter was 75.8 nm.Zeta potential was-19.7 mV.The drug loading was 8.27% and the entrapment ratio was 91.76%.Conclusion The entrapment ratio of GL-SLN and the stability of GL-SLN prepared by conventional rotary-evaporated film-ultrasonication method are high and good.
