Mitochondrial DNA Polymorphism Associated with Longevity in Taklimakan Desert Uygur Centenarians
- VernacularTitle:线粒体DNA 5178A/C,10398G/A多态性与新疆长寿老人的关联研究
- Author:
Nijiati MUYESAI
;
Changchun QIU
;
Zuheng CHENG
;
Wenyu ZHOU
- Publication Type:Journal Article
- Keywords:
Longevity;
MitochondrialDNA;
Uiygur nationality;
Associated study
- From:
Journal of Medical Research
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Sequence variations in mitochondrial DNA genes have been found to influence successful aging and longevity. The aim of this study was to examine whether mitochondrial DNA polymorphisms influenced the longevity in Chinese Uygur population.Methods We genotyped the mt5178A and mt10398G in 277 sampels representing three age group (centenarian, n=65; longevity, n=100; controls, n=112) from Taklimakan desert Uygur centenarians,China Results The distribution frequency of the 5178A in the centenarian (51/65, 78.5%) is slightly higher than in those of controls (63/112,56.3%,P=0.0029) . The frequency of the 10398G were significantly higher among the centenarian(47/65,72.3%)and longevity(68/100,68%) in comparison to the controls(60/112,53.6%,P
