EFFECT OF LYCOPENE ON PREVENTION OF LIPID METABOLIC DISTURBANCE IN RATS AND ITS MECHANISM
- VernacularTitle:番茄红素预防脂代谢紊乱的作用及机制探讨
- Author:
Qiling LIU
;
Ling ZHOU
;
Xinqing XU
- Publication Type:Journal Article
- Keywords:
lycopene;
hepatic lipase;
lipoprotein lipase
- From:
Acta Nutrimenta Sinica
1956;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective mechanism of lycopene by modulating lipid metabolic disturbance in rats. Method The hyperlipidemic rats were induced by high fat diet and were divided into groups given different doses of lycopene. The serum total cholesterd(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), the hepatic lipase(HL) and lipoprotein lipase(LPL)activity in liver were tested by biochemical method, and the expression of low density lipoprotein receptor(LDL-R)in liver was detected by Western blot analyses. Results Lycopene decreased serum TC, TG, LDL-C, and the activity of LPL and HL in three lycopene groups were higher than those in model group, and the high dose group was the highest. Conclusion Lycopene may increase the lipases’activity and the expression of LDL-R, and decrease the deposit of TG and LDL in liver to prevent lipid metabolic disturbance.
