PI3K/AKT and ERK1/2 signaling pathways in the process of cardiomyopathy induced by doxorubicin
- VernacularTitle:大鼠阿霉素所致心肌病过程中PI3K/AKT以及ERK1/2信号通路表达的改变
- Author:
Ping XIANG
;
Liu TU
;
Yuan CHEN
- Publication Type:Journal Article
- Keywords:
doxorubicin;
cardiomyopathy;
cardiotoxicity;
apoptosis;
signaling pathway
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of PI3K/AKT and ERK1/2 signaling pathways in the process of cardiomyopathy induced by doxorubicin(DOX).Methods Twenty SD rats were divided into two groups:DOX group(10 rats that were injected through caudal vein with 2.5 mg/kg DOX,once a week,for 6 weeks)and control group(10 rats).At 5th week after the end of DOX injection,the structural changes and functional damage were examined,and the apoptosis rate of cardiomyocytes and the expression levels of p-AKT and p-ERK1/2 were determined.Results Eleven weeks after the DOX injection,the myocardial pathological changes were mainly myofibrillar loss and cytoplasmic vacuolization.DOX could induce compensated heart function(the value of FS% was 34,P0.05)and Bax to 338%(P
