Relationship of heart rate variability with serum high sensitivity C-reactive protein in aged patients of type 2 diabetes mellitus
- VernacularTitle:老年2型糖尿病患者心率变异性与高敏C反应蛋白关系研究
- Author:
Jin YANG
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
heart rate variability;
high sensitivity C-reactive protein
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between heart rate variability(HRV)and serum high sensitivity C-reactive protein(hs-CRP)in type 2 diabetic aged patients.Methods Totally 30 aged patients with type 2 DM were enrolled in this study who were selected from the outpatients and inpatients of Department of Gerontology in the Third People's Hospital of Chongqing,and another 30 non-diabetic matched individuals were recruited as control.Their serum hs-CRP and 24 hour-electrocardiography were examined.HRV was assessed by calculating the indices based on statistical operation on RR intervals(time domain analysis)from 24-hour Holter recording,including:standard deviation of normal to normal RR intervals(SDNN),standard deviation of 5-minute mean RR intervals(SDANN)and square root of differences between adjacent NN intervals(rMSSD).Linear correlation analysis was carried out between their serum hs-CRP and HRV.Results HRV parameters of type 2 DM patients were significantly lower than those of non-diabetic patients,but hs-CRP values were significantly higher than those of control.Linear correlation analysis indicated that HRV was in a positive correlation with hs-CRP in type 2 diabetic aged patients.Conclusion Altered autonomic nervous function may be associated with altered serum hs-CRP in aged patients with type 2 diabetes mellitus.
