VEGF enhances serum levels of HGF and IL-6 in rats following 50 percent partial liver transplantation
- VernacularTitle:VEGF对大鼠50%肝脏移植术后血清HGF、IL-6浓度的影响
- Author:
Xiaoling DONG
;
Shuguang WANG
;
Yujun ZHANG
;
Yan JIANG
- Publication Type:Journal Article
- Keywords:
partial liver transplantation;
VEGF;
anti-VEGF;
HGF;
IL-6;
rat
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effects of exogenous VEGF on the serum levels of HGF and IL-6 in rats following partial liver transplantation.Methods Totally 180 SD rats were subjected to 50 percent partial liver transplantation,then each 60 rats were treated either with VEGF,anti-VEGF or normal saline.HGF,IL-6 and hepatic biochemical markers were assessed at 0,12,24,72,168 h after operation.Results In the VEGF group,the serum levels of HGF and IL-6 were significantly increased as compared with those of anti-VEGF group or control group.Blockage of endogenous VEGF led to a marked increase of ALT and AST.Conclusion VEGF can markedly increase the secretion of HGF and IL-6,which may be related to its enhancing liver regeneration and improving liver function.
