Association of galectin-3 expression with biological behaviors of squamous carcinoma of esophagus
- VernacularTitle:Galectin-3在食管鳞癌中的表达及其临床意义
- Author:
Fei SHI
;
Guiyong PENG
;
Yonggang SUN
;
Dapeng YAO
- Publication Type:Journal Article
- Keywords:
esophageal carcinoma;
galectin-3;
immunohistochemistry;
reverse transcriptase polymerase chain reaction
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the galectin-3 expression in squamous carcinioma of esophagus and analyze its relationship with clinicopathological characteristics.Methods S-P immunohistochemistry was used to detect the expression of galectin-3 in 80 paraffin-embedded specimens of esophageal carcinoma and 22 specimens of normal tissues adjacent to the benigh lesions of esophagus.RT-PCR was performed to detect galectin-3 mRNA expression in 36 pairs of fresh squamous carcinoma tissues and corresponding adjacent normal mucosa.Results Out of 80 specimens of squamous carcinoma of esophagus,62 specimens had positive expression of galectin-3,with the positive rate of 77.5%(62/80)that was significantly higher than 27.27% in normal esophageal tissues(6/22,P
