Expression of CXCL12 and CXCR4 in salivary adenoid cystic carcinoma and peripheral nerve tissues
- VernacularTitle:CXCL12/CXCR4在涎腺腺样囊性癌及周围神经组织中的表达
- Author:
Zhibing MENG
- Publication Type:Journal Article
- Keywords:
salivary gland neoplasms;
adenoid cystic carcinoma;
chemokines;
receptors;
neural invasion
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between CXCL12/CXCR4 expression and the neural invasion of salivary adenoid cystic carcinoma(SACC).Methods:Totally 41 SACC specimens,30 tongue cancer specimens,20 pleomorphic adenoma specimens and 20 normal nerve specimens were included in the present study.The specimens were made into sections of 4?m and EnVision method was used to detect the expression of the chemokine receptor CXCR4 in SACC sections and the expression of the chemokine CXCL12 in the peripheral nerve tissue sections.Results:The chemokine receptor was highly expressed in ACC cells.The positive rate of CXCR4 was 63.41% in the SACC sections,which was significantly higher than those in the tongue cancer group(36.67%)and the pleomorphic adenoma parotid group(35%)(P
