The changes and clinical significance of glutathione redox-state in patients with chronic heart failure
- VernacularTitle:慢性心力衰竭血浆谷胱甘肽氧化还原状态改变及临床意义
- Author:
Xinye LIU
;
Xun LI
;
Hongxia LI
;
Lianhua HAN
- Publication Type:Journal Article
- Keywords:
heart failure;
glutathione
- From:
Chinese Journal of Practical Internal Medicine
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes and clinical significance of glutathione redox-state in patients with chronic heart failure.Methods A total of 81 hospitalized CHF patients(NYHA heart function grade from Ⅱ to Ⅳ)and a total of 28 paroxysmal supraventricular(PSVT)patients without other diseases(controlled group)were recruited in Cadiovascular Wards of the First Affiliated Hospital of Suzhou University from Jun.2006 to Mar.2007.The plasma concentration of GSH and GSSG was determined by using glutathione reductase recycling method(GR-DTNB).Redox potential(EhGSH/GSSG)was calculated using Nernst equation according to the concentration of reduced and oxidized glutathione.Results(1)The concentration of GSH was significantly lower in CHF group compared with control group(P
