Study on mechanism of action of Wenyang Huoxue Compound Preparation on platelet receptor and signal transduction in coronary heart disease rats with yang deficiency and blood stasis of heart
- VernacularTitle:温阳活血中药复方调控冠心病(心)阳虚血瘀证大鼠血小板内受体、信号转导的作用机制研究
- Author:
Mingxue ZHANG
;
Yanpeng CHANG
;
Hongxin CAO
- Publication Type:Journal Article
- Keywords:
Coronary heart disease with yang deficiency and blood stasis of heart;
Wenyang Huoxue Compound Preparation;
Platelet;
Receptor;
Signal transduction;
Experimental study
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To research the effect of Wenyang Huoxue Compound Preparation on platelet receptor and signal transduction in coronary heart disease rats with yang deficiency and blood stasis of heart.Methods: The coronary heart disease rat models were established by administering high fat diet,subcutaneous injection with pituitrin and being stimulated by cold methods.Then,to observe the effect of Wenyang Huoxue Compound Preparation on platelet receptor and signal transduction.Results: Compared with model group,the concentration of plasma von Willebrand factor(vWF),the content of thromboxane B2(TXB2),the platelet aggregation rate,the molecular number of GPⅡb/Ⅲa and the content of platelet?granularmembrane protein(GMP 140) in Wenyang Huoxue Compound Preparation group decreased apparently(P
