Differences in esophageal visceral sensitivity between nonerosive reflux disease and erosive esophagitis and the relevant mechanism
- VernacularTitle:非糜烂性反流病、糜烂性食管炎患者内脏敏感性的差异及其外周敏化机制
- Author:
Min YANG
;
Zhaoshen LI
;
Dongfeng CHEN
- Publication Type:Journal Article
- Keywords:
esophagitis, peptic;
nerve fibers;
gastroesophageal reflux
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the role of esophageal visceral sensitivity in the pathogenesis of different subtypes of nonerosive reflux disease (NERD), erosive esophagitis (EE), and observe the characteristics and differences of nerve fiber endings of lower esophageal sphincter (LES) to explore the mechanism for peripheral sensitization in mediating the esophageal hypersensitivity. Method 31 NERD patients, 13 EE patients and 12 healthy volunteers were enrolled in the present study. The perception thresholds including the initial perception threshold (IPT) and the maximally tolerated pain threshold (MPT) were determined using the step-wise intraesophageal balloon distention (IEBD) protocol by esophageal barostat. The ultrastructures of nerve fiber endings of various types of synaptic vesicles were investigated with transmission electron microscope (TEM). Results IPT in NERD-H patients was significantly lower than that in NERD-N and controls (P
