Neuroimaging and electroencephalogram features of a patient with Creutzfeldt-Jakob disease: a follow-up study
- VernacularTitle:1例Creutzfeldt-Jakob病的神经影像学与脑电图长期跟踪研究
- Author:
Jiatang ZHANG
;
Chuanqiang PU
;
Senyang LANG
- Publication Type:Journal Article
- Keywords:
Creutzfeldt-Jakob disease;
diffusion weighted imaging;
electroencephalogram
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the characteristics of neuroimaging and electroencephalogram (EEG) features of sporadic Creutzfeldt-Jakob disease (sCJD). Methods CT scan was performed at the 6th week, MRI was performed at the 7th, 9th, 17th and 64th week, regular EEG recording was performed at the 9th week, contineous 24-hour EEG recording was performed at the 11th, 14th, 16th, 37th and 64th week after onset in a patient with the pathological diagnosis of CJD. Regular pattern was analyzed according to the neuroimaging results and EEG. Results a) Diffusion-weighted imaging (DWI) was more sensitive in diagnosis of sCJD than cranial CT, T1-weighted MRI (T1WI), T2-weighted MRI (T2WI), fluid-attenuated inversion recovery (FLAIR) MRI or contrast-enhanced MRI. Abnormalities would not be found in the early stage of CJD in CT, T1-weighted MRI, T2-weighted MRI, FLAIR or contrast-enhanced MRI, but they could be found in the middle stage of CJD. The CT scan and routine MRI might not show any specific feature for the sCJD. b) DWI abnormalities appeared in bilateral cortex and basal ganglia, and changed along with the progression of disease. In late stage of the disease, abnormal aignals in the cortex would disappear, but it was still present in basal ganglia. c) The appearance of periodic discharge of sharp wave complexes (PSD), which could be mathematically described by a sine curve, might be absent in the early and late stage of the disease. Along with the progression of CJD, PSD would be present in a part of a lobe at first and then involve more lobes, and finally the whole brain would be involved. Conclusion Repeated monitoring of DWI and EEG is significant for early diagnosis of CJD.
