Protective effect of Losartan and vitamin E against military overtraining-induced kidney injury in a rats model
- VernacularTitle:氯沙坦及维生素E对高强度军事训练致大鼠肾损伤模型的保护作用
- Author:
Chunhua ZHOU
;
Hong CHEN
;
Jun YANG
- Publication Type:Journal Article
- Keywords:
athletic injury;
kidney;
military medicine;
losartan;
vitamin E
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the preventive and therapeutic effects of losartan and vitamin E on kidney injury induced by overtraining in a rat model. Methods Forty SD male rats were randomly divided into four groups (10 each): control group, model group, losartan group and vitamin E group. Rats in control group were fed with conventional diet. Rats in other three groups were forced to run on the treadmill for 8 weeks, once a day for 20 minutes and 5 days for each week, till exhaustion to induce the kidney injury. Rats in losartan group and vitamin E group were gavaged either with losartan or vitamin E everyday. Urine was collected at the end af each week, urine protein and N-acety-D-glucosaminidase (NAG) were detormined, and the serum urea nitrogen, creatinine (SCr), angiotensin Ⅱ, Na+-K+-ATP-ase activity in kidney were analyzed after 8 weeks' training. Results After 8 weeks' training, the urine protein, NAG in urine, blood urea nitrogen (BUN), SCr were obviously increased in model group, losartan group and vitamin E group as compared with that in control group, while those in model group were higher than that in losartan group and vitamin E group (P0.05). Na+-K+-ATP-ase activity of renal tissue were obvionsly lower in model group and losartan group than that in control group and vitamin E group (P
