Experimental chronic hydrocephalus after intraventricular hemorrhage in rats:establishment of animal model and pathological observation
- VernacularTitle:大鼠实验性脑室出血后慢性脑积水动物模型的建立及病理学观察
- Author:
Guoqi GONG
;
Hui MENG
;
Yongzhi XIA
;
Hua FENG
- Publication Type:Journal Article
- Keywords:
intraventricular hemorrhage;
animal model;
hydrocephalus
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the rat model of chronic hydrocephalus after intraventricular hemorrhage(IVH).Methods Totally 110 Sprague Dawley female rats were divided into 3 groups:IVH group(n=50),saline control group(n=50)and the normal group(n=10).The rats in IVH group were infused autologous whole blood(130 ?l)into the right lateral cerebral ventricle.All rats except the normal group were sacrificed on day 1,3,7,14,28 after operation,and the transverse diameter of the lateral ventricle was measured to evaluate hydrocephalus and the index of ventricle.The pathological changes of the brain were observed.Results Hydrocephalus occurred in 7 out of 10 rats in IVH group at 28 d.The index of ventricle in IVH group(4.51?1.94)was higher than that of saline control group(1.05?0.41)and the normal group(0.79?0.49)(P
