Effect of Irbesartan on cyclooxygenase-2 in aortic atherosclerotic lesion in rabbits
- VernacularTitle:不同剂量厄贝沙坦对兔主动脉粥样硬化中环氧合酶2的影响
- Author:
Lihua LI
;
Han LEI
- Publication Type:Journal Article
- Keywords:
atherosclerosis;
cyclooxygenase-2;
Irbesartan
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of angiotensin Ⅱ type 1 receptor antagonist Irbesartan on the expressions of cyclooxygenase-2(COX-2)in rabbit model of atherosclerosis.Methods Thirty male New Zealand rabbits were randomly divided into five groups:normal control group,high cholesterol group(Group HC),10 mg?kg-1?d-1 Irbesartan group(Group S),20 mg?kg-1?d-1 Irbesartan group(Group M),30 mg?kg-1?d-1 Irbesartan group(Group H).Except the control group,the other four groups were fed with high cholesterol diet to induce atherosclerosis for 14 weeks.Then,the size of aortic atherosclerotic lesions and the ratio of aortic tunica intima to media were measured.RT-PCR,immunohistochemistry and Western blotting were used for COX-2 mRNA and protein levels respectively.Results Compared with Group HC,atherosclerotic lesion size was markedly reduced in Groups M and H(P
