Impact of transplant nephrectomy on panel reactive antibodies
- VernacularTitle:无功能移植肾切除对群体反应抗体的影响
- Author:
Hong LIU
;
Lian LI
;
Rongjie YU
;
Hongwen ZHAO
;
Xiongfei WU
- Publication Type:Journal Article
- Keywords:
kidney transplantation;
panel reactive antibody;
transplantation immunity
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the impact of transplant nephrectomy on panel reactive antibodies and a secondary renal transplantation.Methods Panel reactive antibodies in 15 patients with a failed renal transplant admitted in our hospital between 2004 to 2007 were measured before transplantation,before and 1 month,6 months,12 months after transplant nephrectomy,and the pathological changes were observed after transplant nephrectomy.Results Panel reactive antibodies was increasing after renal transplantation,and reached the highest level one month after transplant nephrectomy,then grandually got down.New HLA allosensitization sites were discovered after transplant nephrectomy.Large amount of C4d was stained in failed transplant.Conclusion Serum PRA increased after transplant nephrectomy.New HLA allosensitization sites were found,which may be useful in HLA matching.
