Long-term morphologic changes in skeletal muscles of SD rats after botulinum toxin A gel injection
- VernacularTitle:肉毒杆菌毒素A水凝胶对大鼠骨骼肌远期作用的形态学观察
- Author:
Huahong ZHONG
;
Jingchang CHEN
;
Heping WU
;
Guanghuan MAI
- Publication Type:Journal Article
- Keywords:
botulinum toxin A;
gel;
the gastrocnemius muscle;
histomorphology;
transmission electron microscopy
- From:Journal of Third Military Medical University
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05).Histopathologic examination showed no changes in the right gastrocnemius muscles injected with BTXA gel,but ultrastructurally the myopathic changes were clearly visible,like diffuse sarcomere disruption and saroplasmic reticulum expanding.The myofibre degeneration showed no remission 12 months after BTXA gel injection.Conclusion BTXA is dissolved in gel evenly.The long-lasting myofibre degeneration in BTXA gel paralyzed muscles may reflect that the paralyzed muscles fail to regain their unique function and recovery of muscle contraction.
