Effects of progesterone on amino acid neurotransmitters released from rat cerebral cortical neurons
- VernacularTitle:孕酮对大鼠大脑皮质神经元氨基酸类神经递质释放的影响
- Author:
Gai XUE
;
Honghai WU
;
Yanning HOU
- Publication Type:Journal Article
- Keywords:
progesterone;
glutamate;
?-aminobutyric acid;
cerebral cortex;
neuron
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of progesterone on the levels of glutamate and ?-aminobutyric acid released from primary cultured rat cerebral cortical neurons.Methods Primary cultured rat cerebral cortical neurons were treated with PROG(10 ?mol?L-1) and the concentrations of amino acid in cell culture media at different time(0.5,1,1.5,2,24,36,48,72 h) were measured by OPA-mercaptoethanol precolumn derivatization technique and HPLC-FLD.Results Compared with control group,PROG treatment significantly reduced the levels of GLU at the time of 1,1.5,2,24,36,48,72 h(P
