Effects of polysaccharide sulfate on cardiovascular diseases induced by type 2 diabetes
- VernacularTitle:藻酸双酯钠对2型糖尿病心血管并发症防治作用的研究
- Author:
Lifeng YU
;
Jinsheng ZHAO
;
Long YU
;
Meimi ZHAO
;
He QI
;
Zhi LI
- Publication Type:Journal Article
- Keywords:
polysaccharide sulfat;
type 2 diabetic;
cardiovascular complications;
nuclear factor kappa B(NF-?B);
intercellular adhesion molecule;
tissue-type plasminogen activator
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the pharmacological mechanism and the effects of polysaccharide sulfat(PSS) on cardiovascular diseases induced by type 2 diabetes mellitus(DM) through observing the risk factors.Methods Type 2 diabetic animal model was established by high-sugar and high-fat diets,combined with injection of small amount streptozotocin(STZ 20 mg?kg-1,iv).Adult male wistar rats were divided into five groups: normal control group,model group,polysaccharide sulfate group,metformin group and lovastatin group.They were treated with exact medicne for 8 weeks,but control group and model group were treated with 0.9% Nacl.During this process,FBG and serum lipid concentrations were measured.22 weeks later,the rats were sacrificed.The activity of tissue-type plasminogen activator(t-PA) and plasminogen activator inhibitor type-1(PAI-1) were detected by chemical methods.The aortas were collected for histopathlogical,immunohistochemical and Western blot studies.Results FBG concentrations and serum lipid(TC,TG,LDL) levels decreased in PSS group as compared from those of model group(P
