Effects of Nimodipine treatment on the expression of neural cell adhesion molecule after the ischemic brain injury in rats
- VernacularTitle:尼莫地平对缺血性脑损伤大鼠神经细胞黏附分子表达的影响
- Author:
Debin HUANG
;
Zhi DONG
- Publication Type:Journal Article
- Keywords:
nimodipine(NDP);
ischemic brain injury;
neural cell adhesion molecule(NCAM);
expression
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the effects of Nimodipine(NDP) treatment on the expression of neural cell adhesion molecule(NCAM) after the ischemic brain injury in rats.Methods One hundred male Wistar rats(180~220g) were randomly divided into four groups:sham operation control group(SOCG,n=10),cerebral ischemia control group(CICG,1,3,7 d,n=30),high and low dose Nimodipine treatment group(H-NTG,L-NTG,1,3,7 d,n=10).Their middle cerebral arteries of CICG and NTG were blocked by filament forming brain injured,the NTG groups were treated with NDP(0.5 mg?kg-1 and 1mg?kg-1),respectively.and then,their cerebral blood flow was reperfused.Their blood vessel shape of cerebri surface was observed and the expression of NCAM was determined,after neurologic impairment(NIP) was scored and regional cerebral blood flow(RCBF) was surveyed,respectively.Results 3 d,7 d PO2 of H-NTG were higher than those of CICG(P
