Effects of all-trans retinoic acid and benazepril on the expression of ?-smooth muscle actin in rats with glomerulosclerosis
- VernacularTitle:全反式维甲酸与苯那普利对肾硬化大鼠肾脏组织?-SMA表达的影响
- Author:
Peng HU
;
Yuanhan QIN
;
Juan PEI
;
Fengying LEI
;
Yusheng PANG
;
Zhenbo FENG
;
Weifang HUANG
- Publication Type:Journal Article
- Keywords:
all-trans retinoic acid;
benazepril;
glomerulosclerosis;
Wistar rat;
?-smooth muscle actin
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of all-trans retinoic acid and benazepril on the expression of ?-smooth muscle actin in rats with glomerulosclerosis.Methods 80 Wistar male Rats were randomly assigned into the following groups: control group,model group,ATRA treatment group and benazepril treatment group,20 rats in each group.GS rats were uninephrectomized and injected with adriamycin(5mg?kg-1) after one week through the tail vein.All rats were sacrificed at the 12th week,GS was evaluated by glomerulosclerosis index(GSI) system.The expression of ?-SMA was assessed by reverse transcription-polymerase chain reaction(RT-PCR) and immunohistochemistry.Results Comparing with control group,the expression of ?-SMA mRNA and protein were decreased significantly in ATRA treatment group and benazepril treatment group(P0.05).Conclusions The postponed effects of ATRA and benazepril on GS were evident and equivalent.
