A Preliminary Investigation of Rifampin liposome in Treatment of Tuberculosis in Mice
- VernacularTitle:利福平脂质体治疗小鼠结核病的初步研究
- Author:
Ruiru SHI
;
Feixu GAO
;
Jiangdong WANG
;
Xin LIU
;
Guolong ZHANG
- Publication Type:Journal Article
- Keywords:
Tuberculosis;
Liposome;
Rifampin
- From:
Journal of Medical Research
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of rifampin liposome in treatment of tuberculosis in mice.Methods Sixty KM mice were infected by H37Rv to prepare tuberculosis model.Rifampin liposome was prepared by thin film dispersing method.Mice were randomly divided into 4 groups(15 mice each):group of normal control,empty liposome control,rifampin(10mg/kg body weight/day) and rifampin liposome(7mg/kg body weight/day).Rifampin and rifampin liposome were put into drinking water,respectively.Mice were sacrificed after one month of oral treatment to analysize the difference of lung weight and to homogenize lung,spleen,liver tissues to test bacteria burden(cfu).Results Lung weight was significantly different in rifampin and rifampin liposome groups when compared with normal control,empty liposome control groups respectively(P0.05) in two drug groups.Things were the same when compared bacteria cfu in lung,spleen and liver tissue.Conclusion Rifampin liposome may become a promising preparation in the treatment of tuberculosis which make it possible to reduce the clinical dose and thus weaken side effects of rifampin.
