The Significance of Combined Detection of Multi-drug Resistance Gene in Gastric Cancer Prognosis Judgment
- VernacularTitle:多药耐药基因联合检测对胃癌预后的判断的意义
- Author:
Haiyan LIU
- Publication Type:Journal Article
- Keywords:
Multi-drug resistance gene;
Gastriccancer prognosis;
Immunohistochemistry
- From:
Journal of Medical Research
2006;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
Objective To study the significance of combined detection of lung resistance protein(LRP),P-glycoprotein(P-gp),glutathione S-transferace-?(GST-?) and topoisomeraseⅡ(TopoⅡ) in gastric cancer prognosis judgment.Methods One hundred and thirty-six patients with human gastric carcinomas were studied for the expression of LRP,P-gp,GST-?and TopoⅡ by using immunohistochemistry.Results There were significant relationships in the positive expression rate of LRP,P-gp,GST-?between high-Medium differentiated adenocarcinoma and Poorly differentiated adenocarcinoma,Mucinous carcinoma,and Undifferentiated carcinoma(P
