Preparation and quality control of flurbiprofen orally disintegrating tablets
- VernacularTitle:氟比洛芬口腔崩解片的制备及质量控制
- Author:
Xiaodan LAI
;
Songqing LIU
;
Hua HUANG
;
Cai LIN
;
Hongjun HE
- Publication Type:Journal Article
- Keywords:
flurbiprofen;
orally disintegrating table;
high-phase liquid chromatography;
content determination
- From:Journal of Third Military Medical University
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare the flurbiprofen orally disintegrating tablets and establish the procedures of controlling the quality.Methods Flurbiprofen orally disintegrating tablets was prepared by wet granulation and it content was determined by HPLC.Results The obtained tablets were fine in the shape and smooth in the surface.Their hardness was 2 kg,the disintegrating time was about 30 s.The linear correlation was in a range of 1.0-10.0 ?g/ml,r=0.999 9.The average recovery was 99.32%,RSD=1.09%(n=7).Conclusion Our methods of flurbiprofen orally disintegrating tablets are simple and feasible in preparation and quality control.
