Fish oil ameliorates the intra-abdominal sepsis and hypertension-induced ileus
- VernacularTitle:鱼油对改善腹腔感染并发腹腔高压时肠蠕动功能障碍的影响
- Author:
Zheng LOU
;
Jieshou LI
- Publication Type:Journal Article
- Keywords:
Fish oil;
Intra-abdominal sepsis;
Intra-abdominal hypertension;
Intestinal motility;
Interstitial cells of Cajal
- From:
Parenteral & Enteral Nutrition
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether the fish oil improves intestinal motility function during intra-abdominal sepsis and hypertension.Methods: 25 rats were divided into three groups.The rats were supplemented by gavage with: ①normal saline as control group(n=9);②fish oil(0.3%,n=8)and ③fish oil(0.6%,n=8)for 4 weeks before operation.The rats were killed on the 24th hour after operation.In vitro ileual smooth muscle contractions were recorded.Ileum sections were assessed pathologically.Immunopositivity of c-kit as markers of ICC-MY by confocal microscopy were evaluated.Results: In the bowel segment with NS,muscles showed a significant reduction in the frequency of contraction compared to that with FO.This change was associated with the changes of ICC-MY network.Conclusion:The intestinal motility may be protected by an enteral fish oil nutrition through attenuating injury of ICC-MY network.
