Expression of neuroglobin in cerebral cortex of traumatic brain injury rats
- VernacularTitle:大鼠脑外伤后伤灶周围皮质脑红蛋白的表达变化
- Author:
Xingjun FENG
;
Dingbiao ZHOU
;
Aijia SHANG
- Publication Type:Journal Article
- Keywords:
neuroglobin;
brain injuries;
immunohistochemistry
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of neuroglobin (Ngb) in cerebral cortex of traumatic brain injury rats, and investigate the role of neuroglobin in brain injuries. Methods A traumatic brain injury rat model was constructed with Feeney's method. Fifiteen experiment animals were divided randomly into normal control group, 12h-post-trauma group and 36h-post-trauma group (5 each). Immunohistochemistry and image analysis techniques were used to measure the area, optic density (OD) value and integrated optic density (IOD) value of Ngb immunoreactive products in primary somatosensory cortex (S1) and retrosplenial granular b cortex (RSGb), which was located in the inner side and out side of traumatic brain injury cavity in coronal section of rat brain respectively. Results Ngb immunoreactive products were significantly increased after brain trauma, especially in 36h-post-trauma group. The image analysis showed that there was no significant difference of immunoreactive product area in the 3 groups (P
