Effect of PTS on praxiology, pathomorphology and serum IL-6 in rats with middle cerebral artery occlusion
- VernacularTitle:三七三醇皂苷对大脑中动脉梗塞大鼠行为学、病理形态学及血清白细胞介素-6的影响
- Author:
Weimeng ZOU
;
Jianying ZHAI
;
Fangyuan CUI
;
Xiling WANG
;
Lingqun ZHU
;
Yihuai ZOU
- Publication Type:Journal Article
- Keywords:
PTS;
Cerebral ischemia;
IL-6;
MCAO;
Experimental study
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of PTS on the related pathophysiological changes and serum IL-6 level at different time points after the middle cerebral artery occlusion (MCAO) in rat’s brain.Methods:The model of focal cerebral ischemia of rat was established by the suture-occluded method.The effect of PTS on the behavioral disturbance,the pathological change of ischemia tissue and the level of serum IL-6 at different time points(3d,7d,28d) after MCAO and cerebral ischemia in rats were studied.ResultsAfter MCAO,different degrees of motion disturbances were observed in all rats.The infarct spot can be observed in all groups except the normal.The nerve cell necrosis can be found in all rats after 24 hour of MCAO.The result showed that PTS could improve the degree of motion disturbance,reduce the infarct spot obviously;after MCAO,the serum IL-6 were increased obviously but could be reduced by PTS.Conclusion:PTS can protect the neurons,reduce and eliminate the infiammatory reaction of cerebral ischemia cascade reaction effectively,which may relate to its inhibiting effect on cell factors such as IL-6 production after cerebral ischemia.
