Association of Pro12Ala mutation in peroxisome proliferator-activated receptor-?_2 with obesity in Chinese population
- VernacularTitle:过氧化物酶体增殖体激活受体-?_2基因Pro12Ala多态性与肥胖的关系
- Author:
Zhihua AI
;
Dianchun FANG
;
Zhonghui ZHANG
- Publication Type:Journal Article
- Keywords:
peroxisome proliferator-activated receptor;
gene mutation;
obesity
- From:Journal of Third Military Medical University
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the polymorphism of peroxisome proliferator-activated receptors-?2(PPAR-?2) and its association with obesity in Chinese population.Methods According to BMI,89 subjects who are in normal body weight range and 116 overweighted and obese subjects were included in this study.Their Pro12Ala mutation in the PPAR-?2 gene was detected by PCR restriction fragment length polymorphism.Results Allele frequency of Ala mutation of PPAR-?2 in overweighted and obese subjects(qA=11.64%) was significantly higher than that of normal body weight group(qA=5.06%,P
