Effect of LYS polysaccharides on dementia-related gene expressions in SAMP8 mouse brain
- VernacularTitle:龙眼参多糖对SAMP8鼠脑组织痴呆相关基因表达的影响
- Author:
Zhongshi HUANG
;
Yang JIAO
;
Shijun ZHANG
;
Weizhe JIANG
;
Renbin HUANG
- Publication Type:Journal Article
- Keywords:
LYS polysaccharides;
dementia;
gene expression;
amyloid precursor protein;
presenilin 1;
presenilin 2;
apolipoprotein E
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the effects of LYS polysaccharides on expressions of APP, PS1, PS2 and ApoE in SAMP8 mouse brain. Methods 50 6-month-old SAMP8 mice were used and divided randomly into 5 groups: SAMP8 untreated control group, huperzine A control group, low-, mid-and high-dose groups of polysaccharides, with 10 mice in each group. 10 6-month-old SAMR1 mice were used as normal control. After each group was treated by corresponding drug for 40 days continuously, the mRNA contents of APP, PS1, PS2 and ApoE in brain tissue were assayed by reverse transcription polymerase chain reaction.Results The low-, mid-and high-dose groups of polysaccharides could reduce the mRNA contents of APP, PS1 and PS2, which showed a dose-effect relationship in some degrees. But it could not affect the content of ApoE. Conclusion LYS polysaccharides could inhibit the expressions of APP, PS1, and PS2 in SAMP8 mouse brain.
