Effects of doxazosin enantiomers on the rabbit isolated detrusor strips
- VernacularTitle:多沙唑嗪对映体对兔离体膀胱逼尿肌的作用及机制
- Author:
Haigang LU
;
Ding ZHAO
;
Leiming REN
- Publication Type:Journal Article
- Keywords:
doxazosin;
enantiomer;
detrusor;
phenylephrine;
electric field stimulation;
rabbit
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). Phenylephrine induced contractile responses in a concentration-dependent manner in the dorsal detrusor strips, but not in the ventral detrusor strips. S-doxazosin, R-doxazosin and rac-doxazosin at 1 ?mol?L-1 antagonized the phenylephrine-induced contractile responses competitively in the dorsal detrusor strips, and their pKB values were 7.44?0.19, 7.39?0.14 and 7.38?0.30, respectively. Three pKB values of doxazosin and its enantiomers were not significantly different from each other. Electric field stimulation produced a steady contractile response that was completely inhibited by tetrodotoxin at 0.3 ?mol?L-1. S-doxazosin, R-doxazosin and rac-doxazosin significantly inhibited the contractile responses to electric field stimulation in the dorsal detrusor strips of the rabbit urinary bladder(P0.05). However, S-doxazosin, R-doxazosin and rac-doxazosin did not affect the responses to electric field stimulation in the ventral detrusor strips. Conclusion The pKB value of S-doxazosin against phenylephrine-induced contraction via-adrenoceptors is same to R-doxazosin and rac-doxazosin, and the three agents are able to inhibit the adrenergic contraction induced by electric field stimulation in dorsal detrusor strips of the rabbit urinary bladder.
