Comparison of distributions of muscle injection and intravenous administration of human mesenchymal stem cells in denervated muscles of the sciatic nerve injured rats
- VernacularTitle:比较不同方式移植的人间充质干细胞在大鼠失神经支配的骨骼肌的分布及对坐骨神经损伤的影响
- Author:
Xiaoxuan LIU
;
Dongsheng FAN
;
Jun ZHANG
;
Juyang ZHENG
;
Tiemin MA
- Publication Type:Journal Article
- Keywords:
Mesenchymal stem cell transplantation;
Muscle, skeletal;
Sciatic neuropathy;
Electro- myography;
Denervation
- From:
Journal of Peking University(Health Sciences)
2004;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05). However, compound muscle action potential (CMAP) amplitude in ims injected group wa s si gnificantly higher as compared with the other two groups[ims injected group (12.50?2.06) mV, iv group (1.50?0.20) mV, control group (10.13?4.04) mV, F=6.347, P=0.033]. The MSC s were able to be observed only in ims injected tissues 3 weeks after implantati on (A large number of small undifferentiated cells were found outside the myofib ers and some were found between the cells.) The atrophy of gastrocnemius in ims injected group was much less severe than that of the other 2 groups. The diameter of muscle fibers was significantly longer on d60 (F=4.537,P=0.021).Conclusion:Intra- muscular injection of MSC was well distributed in denervated muscle, which provides a newway of nerve regeneration in the rat model of sciatic nerve injury.
