The Expression of P450arom in Human Ovarian Endometriosis and the Relation Ship with its Estrogen Aabnormal Synthesis Locally
- VernacularTitle:内异症中芳香化酶的表达与其局部雌激素异常合成的关系
- Author:
Xiaoling LI
;
Yali DENG
- Publication Type:Journal Article
- Keywords:
Ovarian endometriosis;
P450arom;
Immunohistochemical assay;
RT-PCR
- From:
Journal of Medical Research
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of P450arom(P450A)protein and mRNA in human ovarian endometriosis and normal endometrium and the relationship with its local estrogen abnormal synthesis.Methods PT-PCR was used to assess P450arom messenger RNA(mRNA)expression of 45 ovarian endometriosis and 35 normal eutopic endometrium;immunohistochemical assay was performed to locate and examin the protein expression of P450arom in the above cases.Results P450A mRNA level was higher in the ectopic endometrium than that in eutopic endometrium(P
