Influences of Tidal Volume on Contents of PMN,TNF-?,IL-6 and IL-8 in Bronchoalveolar Lavage Fluid After Closed Circuit Anesthesia in Infants
- VernacularTitle:潮气量对婴儿循环紧闭麻醉后支气管肺泡灌洗液中PMN、TNF-?、IL-6及IL-8含量的影响
- Author:
Xiaoshu SHEN
;
Liyong YUAN
;
Guo GAN
;
Xiamin WANG
- Publication Type:Journal Article
- Keywords:
Tidal volume;
Infant;
Closed circuit anesthesia;
Bronchoalveolar lavage fluid;
Polymorphonuclear neutrophil leukocyte;
Tumor necrosis factor;
Interleukin-6;
Interleukin-8
- From:
Journal of Medical Research
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective The author seeked the suitable tidal volume in order to decrease mechanical ventilation-induced lung injury during closed circuit anesthesia in infants.Methodes 50 infants who practiced selective orthopedics operation randomly divided into traditional mode(12~15ml/kg,groupT,n=25)and low tidal volumes(7~8ml/kg,groupL,n=25).The bronchoalveolar lavage fluid of intants were collected immediately after tracheal intubation(T1)and before tracheal extubation,respectively.Interleukin-6 and interleukin-8 in the bronchoalveolar lavage fluid were determined by enhancement solid-phase enzyme immunoassay action(EASIA),TNF-? in the bronchoalveolar lavage fluid were determined by euzymelinked immunosorbent assay(EIA).The numbers of polymorphonuclear neutrophils in the bronchoalveolar lavage fluid of intants were examined.The infants' SpO2,arterial blood pressure and PetCO2 were monitored continuously.Arterial blood gas was analysised.The time of analepsia and complications of lung were observed after operation.Results PaCO2、PetCO2 in groupL were higher than that in groupT,pH in groupL lower than that in groupT at 30 min,60 min,120 min after mechanical ventilation and before extubation,respectively.The contents of PMN,TNF-?,IL-6 and IL-8 in BALF collected at T2 more than that at T1 in groupT.The contents of PMN,TNF-?,IL-6 and IL-8 in BALF in groupL less than that in groupT at T2(P
