A Study on the Relationship between the Expression of Matrix Metalloproteinase-9 in Rat Brain and the Pathogenesis of Epilepsy
- VernacularTitle:大鼠脑基质金属蛋白酶-9表达与癫痫发病机制关系的研究
- Author:
Naizhi ZHENG
;
Huijuan ZHANG
;
Min WANG
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase-9;
Dexamethasone;
Epilepsy;
Pathogenesis
- From:
Journal of Medical Research
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the expression of matrix metalloproteinase-9 in rat brain and pathogenesis of epilepsy.Methods The expression of matrix metalloproteinase-9 in hippocampus was observed by immunochemistry in normal and epilepsy rat.Meanwile,the effects of dexamethasone before epilepsy on the expression of MMP-9 in hippocampus was evaluated.Results The expression of MMP-9 in hippocampus were fewer in normal rat brain.The expression of MMP-9 had increased in hippocampus after epilepsy 24h.It had increased obviously in dentate gyrus(DG)after epilepsy 72h than 24h(P0.05).Dexamethasone suppressed the expression of MMP-9 in hippocampus.Conclusion The expression of MMP-9 in rat brain participates in immunopathogenesis of epilepsy by affecting brain immunoreaction,leading to the change of neuronal response and synapse remodeling in hippocampus,regulating brain nervous cell excitability.Dexamethasone plays a prominent suppressant role in the processes.
