Design and synthesis of demethyl bryoanthrathiophene, a new potential angiogenesis inhibitor
- VernacularTitle:血管生成抑制剂候选物——去甲苔藓蒽噻吩的设计合成
- Author:
Shenglin LUO
;
Rongxin QIN
;
Xiangdong ZHOU
- Publication Type:Journal Article
- Keywords:
bryoanthrathiophene;
1,8-dihydroxy-9,10-anthraquinone;
demethyl bryoanthrathiophene;
decarboxylization
- From:Journal of Third Military Medical University
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To design and synthesize a new potential angiogenesis inhibitor, demethyl bryoanthrathiophene. Methods Target molecule-demethyl bryoanthrathiophene was synthesized in 5 steps using 1,8-dihydroxy-9,10-anthraquinone as the starting material, 5,7-dihydroxy-1-carboxyl-6-oxo-6H-anthra thiophene as the key intermediate and decarboxylization as the key step. Results The target molecule was synthesized with a total yield of 10.1% and identified by MS, IR, UV, 1H-NMR, 13C-NMR and 2D-NMR. Conclusion Our synthesis of demethyl bryoanthrathiophene is based on an easily-acquired starting material and accomplished with a simple synthetic route.
