Highly efficient synthesis of marine natural product,24-methylenecholesterol
- VernacularTitle:海洋天然产物24-亚甲基胆固醇的高效合成
- Author:
Juanjuan YUE
;
Xiangdong ZHOU
- Publication Type:Journal Article
- Keywords:
hyodeoxycholic acid;
24-methylenecholesterol
- From:Journal of Third Military Medical University
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To synthesize a marine natural product, 24-methylenecholesterol. Methods The target molecule was synthesized in 7 steps using hyodeoxycholic acid as the starting material, 3?-(tetrahydropyran-2-yloxy)-cholest-5-ene-24-ketone as the key intermediate and isopropylation as the key step. Results The target molecule was synthesized with a total yield of 66% and confirmed by MS, IR, 1HNMR and 13CNMR. Conclusion Our synthesis of 24-methylenecholesterol is characterized by easily acquired starting material, short synthetic route, high yield and atom-economic.
