Effects of QDTMT on brain natriuretic peptide and ventricular remodeling of acute myocardial infarction in rabbit
- VernacularTitle:芪丹通脉片对急性心肌梗死兔脑钠肽和心室重构的影响
- Author:
Qian XIAO
;
Zongren WANG
;
Chao WANG
- Publication Type:Journal Article
- Keywords:
coronary;
myocardial infarction;
atrial natriuretic factor;
ventricular remodeling
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of Qidantongmai Tablet (QDTMT, a Chinese patent medicine) on the dynamic changes in plasma brain natriuretic peptide (BNP) after acute myocardial infarction (AMI) in rabbit induced by ligation of coronary artery, and to explore its influences on ventricular remodeling. Methods Thirty-six healthy rabbits were randomly divided into six groups with six animals for each group: normal group, sham operation group, model group (AMI group, reproduced by ligation of left circumflex branch of the coronary artery), control group (diltiazem hydrochloride group), high dose QDTMT group and low dose QDTMT group. The preventive effect of QDTMT on AMI and its impact on BNP and ventricular remodeling were then investigated. Results ① In high and low dose QDTMT groups, the heart rates increased, the systolic pressure and the pressure differentiation in left ventricle increased obviously, which were significantly different with that of the model group (P
