Clinical investigation of the correlation between TNF-? and proteinuria in patients with chronic glomerulonephritis treated with angiotensin Ⅱ blockers
- VernacularTitle:血管紧张素Ⅱ阻断剂治疗慢性肾小球肾炎时TNF-?和蛋白尿的相关性研究
- Author:
Daoyou ZHANG
;
Yanlang YANG
;
Licai YANG
;
Haihong XU
;
Yuwei WANG
- Publication Type:Journal Article
- Keywords:
chronic glomerulonephritis;
tumor necrosis factor-?;
proteinuria;
angiotensin Ⅱ
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effects of angiotensin Ⅱ(AngⅡ)blockers on TNF-? and the relationship between TNF-? and proteinuria in patients with chronic glomerulonephritis(CGN).METHODS:32 patients examined by biopsy as primary CGN with proteinuria were treated by benazepril,valsartan or combination with benazepril and valsartan for 8 to 12 weeks respectively.The TNF-? levels in serum and urine,24 hours proteinuria quantity,and serum creatinine level were assayed and recorded respectively before and after 8 to 12 weeks therapy.RESULTS:The TNF-? levels in serum and urine and 24 hours proteinuria quantity were reduced significantly after therapy [(7.8?3.9)vs(5.0?1.6)fmol/mL,(11.9?6.8)vs(8.3?3.5)fmol/mL,(2.6?2.0)vs(1.0?0.5)g,respectively;P
