Research progress in the quantitative structure-antitumor activity relationship studies of taxol derivatives
- VernacularTitle:紫杉醇类衍生物的定量结构-抗癌活性关系研究进展
- Author:
Yan LI
;
Yonghua WANG
;
Hua FANG
;
Lanting LI
;
Shuwei ZHANG
- Publication Type:Journal Article
- Keywords:
taxol;
taxoid;
molecular modeling;
QSAR
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The up-to-date quantitative structure-antitumor activity relationship studies of taxol analogues based on molecular modeling techniques were reviewed in the present paper. Both the common understandings and the debates about the contributions of several key structural groups, including the C13 side chain, the substituents of C14, C2 and C10 as well as the oxtane ring to the biological activities of taxol derivatives were summerized. In addition, the studies about other factors influencing the activity except for the structure and the classification research of the molecules were also discussed.
