Genotoxicity of Liquid Formaldehyde on Brain Cells of Goldfishs
- VernacularTitle:液态甲醛致金鱼脑细胞遗传毒性的研究
- Author:
Zhongzhen LI
;
Ling LI
;
Liming WANG
;
Shumao DING
;
Xu YANG
- Publication Type:Journal Article
- Keywords:
Liquid for maldehyde;
Brain cell;
DNA damage;
Single cell gel electrophoresis
- From:
Journal of Medical Research
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore theDNA damage of brain cells of goldfishs through formaldehyde exposure.Methods The goldfishs were treated with liquid formaldehyde at different concentrations(0.01 mmol/L,0.1 mmol/L和1mmol/L)for three days.Single cell gelelectrophoresis technique(comet assay)was used to test the DNA damage of the brain cells.Results Formaldehyde caused significant DNA strand break at the concentration of 0.01mmol/L,0.1mmol/L and 1.0mmol/L.Conclusions Formaldehyde was both a DNA strand breaker when the concentration is higher,it may cause crosslinkagent to the brain in vivo.
