Clinical Characteristics of Drug-fever Caused by ?-Lactams Antibiotics
- VernacularTitle:?-内酰胺类抗生素致药物热的临床特征
- Author:
Hao CHEN
;
Zhenyi REN
- Publication Type:Journal Article
- Keywords:
?-lactams;
Drug-fever;
Clinical characteristics
- From:
Journal of Medical Research
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the clinical characteristics of drug-fever caused by ?-lactams antibiotics and provide the basic information for diagnosis of patients with drug-fever,and profile the drug fever due to antimicrobil agent.Methods In this study,64 hospitalized cases between 2000 and 2006 were enrolled who had drug-fever during antiinfective treatment.Results Most medications can cause fever,so as ?-lactams Antibiotics,with or without concomitant clinical manifestations.The fever could arise from the drug's pharmacologic action,its effects on thermoregulation,a local complication following parenteral administration,or an idiosyncratic response.Patients with drug-fever caused by ?-lactams,their temperature droped to normal level while ?-lactams discontinued for about 24h~48h,and without any linger effect.Conclusions Drug-fever is mainly caused by ?-lactams antibiotics like piperacillin sodium.It is important that doctors should bear the drug-fever in mind to avoid misdiagnosis.
