The Study on Synthesis on 20(S)-9-nitrocamptothecin
- VernacularTitle:20(S)-9-硝基喜树碱的合成研究
- Author:
Jian LI
;
Weiyan QIU
;
Zheming HUAI
- Publication Type:Journal Article
- Keywords:
20(S)-9-nitrocamptothecin;
Nitration mixed;
Purification
- From:
Journal of Medical Research
2006;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
20(S)-9-nitrocamptothecin was synthesized from camptothecin by nitration reaction using mixed nitrate salts in sulfuric acid medium.The yield was raised from 31% to 40% after chromatographic purification treatment.The best reaction conditions was as follows:0.5 g of camptothecin;30ml of sulfuric acid;0.007mol of nitrate salts(NH4NO3/CaNO3=1/1).The reaction was completed in 24h at 20℃.The advantage of this method is high yield and easily purification.
