Effect of FeixianFang on MMP-1,MMP-2 and TIMP-1,TIMP-2 in rats model of pulmonary fibrosis induced by bleocin
- VernacularTitle:肺纤方对博莱霉素大鼠肺纤维化模型基质金属蛋白酶1、2及组织金属蛋白酶抑制剂1、2的影响
- Author:
Xiaomei ZHANG
;
Liangduo JIANG
;
Wei ZHANG
;
Jianjun WU
;
Xiangfeng LU
- Publication Type:Journal Article
- Keywords:
Pulmonary fibrosis;
FeixianFang;
MMP-1;
MMP-2;
TIMP-1;
TIMP-2;
TCM therapy
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To observe the effect of FeixianFang on matrix rebuilding of pulmonary fibrosis in rats.Methods: Rats were randomly divided into the model group,the sham operation group,the FeixianFang group and the prednisone group.Pulmonary fibrosis model was set up by intratracheal injection of bleocin.On the 14th,28th and 45th day,MMP-1,MMP-2 and TIMP-1,TIMP-2 in the serum were detected.Results: FeixianFang can significantly reduce the level of MMP-1,MMP-2 and TIMP-1,TIMP-2 in the serum of rats with pulmonary fibrosis.Conculusion: FeixianFang can inhibit matrix rebuilding in pulmonary fibrosis rats.
