Primary pharmacological studies on the saponins from the solid fermented roots of Radix Notoginseng produced in Yunnan province
- VernacularTitle:滇产三七固态生物转化产物的初步药理研究
- Author:
Weiguang MA
;
Yunli ZHAO
;
Xia WANG
;
Wei LIAO
;
Jianhua SHANG
;
Zhipu HUANG
;
Youliang PENG
;
Qingzhi ZHANG
;
Chao ZHANG
- Publication Type:Journal Article
- Keywords:
Radix Notoginseng;
Biotransformation;
Pharmacological studies
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the pharmacodynamic action of Radix Notoginseng after fermented by different strains bioconversion.Methods:The models of cerebral ischemia and hypoxia were established,thrombosis in vivo were induced by collagen-Adr,ventricular fibrillation of mice by chloroform,and perfusion experiment of the ex vivo heart of cavia cobaya was used.Results:100,200mg/kg doses of all samples had protective effects on ischemia and hypoxia mice,1# sample can inhibit thrombosis induced by collagen-adrenaline obviously after intraperitoneal injection in dosage of 200mg?kg-1?d-1 for 5days.All groups significantly reduced the incidents of ventricullar fibrillation induced by chloroform in mice except 100mg/kg dose of 1#,furthermore,compared with control high dose group(5#),the incidents of high dose groups of 3、4# deceased significantly.All samples had the effect of dilating coronary artery,but there effects on myocardial contractile force and cardiac preload were different.Conclusion:The primary cardiovascular related pharmacological researches demonstrated the vary action changes of 1-4# samples compared with the sample 5#.This result has revealed that the chemical structure of Radix Notoginseng transformed and that is coincide with initial analysis of phytochemical analysis.
