Clinical study on the hypothesis of "endogenous collateral wind" on acute coronary syndrome
- VernacularTitle:急性冠脉综合征“络风内动”假说临床研究
- Author:
Xian WANG
;
Dayi HU
- Publication Type:Journal Article
- Keywords:
Endogenous collateral wind;
Acute coronary syndrome;
Coronary artery disease;
Luoheng dripping pills
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To propose the hypothesis of "endogenous collateral wind" based on the pathomechanism of thrombogenesis complicated by ruptured plaque on acute coronary syndrome(ACS) and the theory of traditional Chinese medicine.Methods: Patients of coronary artery disease with successful coronary angiography(CAG) and intravascular ultrasound(IVUS) was made the differential diagnosis such as blood stasis,blood stasis due to phlegm obstruction and endogenous collateral wind.The levels of plasma inflammatory marker were measured to study the charactristic of "endogenous collateral wind".The prescription principle of Luoheng dripping pills was promoting blood circulation to expel wind-evil and remove wetness under guidence of "endogenous collateral wind" hypothesis.Patients with unstable angina were randomly divided into 3 groups based on therapeutic methods:conventional therapy group,luoheng dripping pills group and Tongxinluo capsule group.Results: There were characteristic changes of severity of coronary artery stenosis,the types of ACC/AHA lesion and Levin lesion,remodeling index,positive or negative remodeling percentage measured by IVUS,the plasma levels of plasma inflammatory marker measured by ELLSA in patients with endogenous collateral wind syndrome.The total effective rate of improved angina in luoheng dripping pills group was significantly higher than those in other two groups.The levels of plasma inflammatory marker were significantly lower in luoheng dripping pills group.Conclusion: There were some pathological found of the hypothesis of "endogenous collateral wind" on acute coronary syndrome.It provides the evidences that patients with coronary artery disease were treated with expelling wind-evil and removing wetness.
