Methods on enhancing success rate and survival rate of rat model of myocardial infarction
- VernacularTitle:提高大鼠心肌梗死模型成功率及存活率的研究
- Author:
Ping XIANG
;
Yinzi SONG
;
Yuan CHEN
;
Liu TU
;
Gaohui ZHU
- Publication Type:Journal Article
- Keywords:
coronary artery ligation;
myocardial infraction;
lidocaine;
success rate
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of different ligation position,vena coronaria variation and lidocaine on myocardial infarction size and mortality in rats Methods Totally 120 male SD rats were divided into four groups with 30 rats in each group: low ligation with invisible vena coronaria,low ligation with visible vena coronaria,high ligation,and high ligation plus lidocaine Results MI was successfully created in 930% rats of high ligation groups and in 673% rats of low ligation groups The mortality was 433% in rats of high ligation groups,only 133% in rats when lidocaine in use Conclusion High ligation increases the success rate of rat model of myocardial infarction and the application of lidocaine decreases the mortality of the rat model
