Effects of taurine magnesium coordination compound on potassium current in guinea pig ventricular cardiomyocytes
- VernacularTitle:牛磺酸镁对豚鼠心室肌细胞钾离子通道的影响
- Author:
Lei YU
;
Yongqiang YIN
;
Xin LI
;
Weizhen GAO
;
Yi KANG
;
Jianshi LOU
- Publication Type:Journal Article
- Keywords:
taurine magnesium coordination compound(TMC);
arrhythmia;
ion channel;
whole-cell patch clamp technique
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the antiarrhythmic mechanism of taurine magnesium coordination compound(TMC)on the potassium current in single ventricular myocytes of guinea pig.Methods Whole-cell patch clamp was used to record IK,IK1 in single ventricular myocytes of guinea pig.Results In ventricular myocytes of guinea pig,IK was decreased from(8.67?1.04)pA/pF to(6.31?1.16)pA/pF at +70 mV.TMC had no effect on the IK1.Conclusions TMC had inhibitory effect on IK directly and this effect maybe resulted in prolonging the action potential duration(APD)and effective refractory period(ERP).It could be one of the basis of antiarrhythmic effect of TMC.
