Simvastatin ameliorates rat ventricular remodeling after myocardial infarction:the role of phosphorylating extracellular signal-regulated kinase1/2
- VernacularTitle:辛伐他汀改善大鼠心肌梗死后心室重塑与p-ERK1/2的关系
- Author:
Xuelian XU
;
Shu QIN
;
Han LEI
;
Qiang YE
;
Maohui ZHANG
- Publication Type:Journal Article
- Keywords:
simvastatin;
myocardial infarction;
ventricular remodeling;
extracellular signal-regulated kinase1/2
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effect of simvastatin on ventricular remodeling in rats after myocardial infarction,and the association between this effect and phosphorylating extracellular signal-regulated kinase1/2(p-ERK1/2).Methods Myocardial infarction(MI)rat models were successfully induced by ligation of anterior descending coronary artery.The treated rats were randomly divided into 4 groups(n=8~10):MI only group,MI plus 20 mg Sim group(20 mg?kg-1?d-1),MI plus 40 mg Sim group(40 mg?kg-1?d-1),and sham-operated group.After 4 weeks,the rats were checked by echocardiography including LVEDd,LVPWd,LVEF,FS,SV and CO.Myocardial p-ERK1/2 was also examined by immunohistochemistry and Western blot.Results Compared with sham-operated group,LVEDd,LVPWd in other groups were significantly increased(P
