The effect of sibutramine hydrochloride on expression of hypothalamus orexin system gene in high-fat dietary obesity rats
- VernacularTitle:盐酸西布曲明对高脂肥胖大鼠下丘脑增食欲素系统的影响
- Author:
Zhou CHEN
;
Liping LIAO
;
Libin LIU
- Publication Type:Journal Article
- Keywords:
sibutramine hydrochloride;
obesity;
orexin;
gene expression
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the effect of sibutramine hydrochloride on hypothalamus orexin system gene in high-fat dietary obesity rats.Methods SD rats were fed with high-fat diet to induce obesity model.Then,the rats were divided into two groups,the treatment group with sibutramine(8 mg?kg-1,ig)and control group with NaCl(ig)for 4 weeks.All rats' weight,blood fat and glucose were measured,prepro-orexin and its receptors mRNA expression in the hypothalamus were assessed by semi-quantity RT-PCR.Results Sibutramine not only decreased the obesity rats' weight and the level of serum lipid and glucose,but also increased the level of prepro-orexin mRNA expression in obesity rats.There was no difference in mRNA expression of both orexin receptors in each group.Conclusions Sibutramine hydrochlorid has an anti-obesity effect in high-fat obesity rats,which may be related to the increase of prepro-orexin gene mRNA expression level.
